Psychiatric Drug Innovation In Crisis

“The interest in psychedelics may also have something to do with a growing sense of frustration over the lack of promising new psychiatric drugs in the pipeline. Many of the current drugs are based on compounds discovered serendipitously in the 1950s, and true innovation has been so hard to come by that many companies are giving up.”

:: Wired covers the MAPS Conference ::

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BONUS QUOTE

“Psychedelic scientists still face obstacles at every step of the process, from getting research funding, to getting the compounds themselves, to publishing the findings, says psychiatrist David Nutt of Imperial College London. Nutt recently won a large grant from the British government to conduct a clinical trial of psilocybin for depression. But red tape is holding it up.

To comply with the law, Nutt has to find a manufacturer who’s capable of making medical-grade psilocybin and has all the proper permits to make controlled substances. So far, he hasn’t found one. The study is on hold.

“The illegality of these drugs has profoundly distorted research and continues to do so,” Nutt said at the conference. “It’s one of the greatest scandals in modern research.”

—-

I’d say that not publishing negative data is a substantially bigger scandal but this is certainly something that should be of concern to people with depression.

From the NYTimes:

WASHINGTON — When Secretary of State Hillary Rodham Clinton fractured her right elbow after slipping in a State Department garage in June 2009, she returned to work in just a few days. Her arm in a sling, she juggled speeches and a trip to India and Thailand with physical therapy, rebuilding a joint held together with wire and pins.

It was vivid evidence of Mrs. Clinton’s indomitable stamina and work ethic — as a first lady, senator, presidential candidate and, for the past four years, the most widely traveled secretary of state in American history.

But after a fall at home in December that caused a concussion, and a subsequent diagnosis of a blood clot in her head, it has taken much longer for Mrs. Clinton to bounce back. She was released from a hospital in New York on Wednesday, accompanied by her daughter, Chelsea, and her husband, former President Bill Clinton. On Thursday, she told colleagues that she hoped to be in the office next week.

Her health scare, though, has reinforced the concerns of friends and colleagues that the years of punishing work and travel have taken a heavy toll. Even among her peers at the highest levels of government, Mrs. Clinton, 65, is renowned for her grueling schedule. Over the past four years, she was on the road for 401 days and spent the equivalent of 87 full days on a plane, according to the State Department’s Web site.

In one 48-hour marathon in 2009 that her aides still talk about, she traveled from talks with Palestinian leaders in Abu Dhabi to a midnight meeting with Prime Minister Benjamin Netanyahu in Jerusalem, then boarded a plane for Morocco, staying up all night to work on other issues, before going straight to a meeting of Arab leaders the next morning.

—-> Fears That Work Has Taken Toll via The NYTimes 

I think that’s a particularly well written piece but it tells me basically nothing about how Hilary Clinton has performed as secretary of state.  In fact, I’ve seen a lot of articles talking about how hard she works (and should thus run for pres in 2016) but never anything substantiative about her accomplishments.  Not saying they aren’t there, just haven’t heard of them.

Word of the Day: Proscenium

pro·sce·ni·um (pr-sn-m, pr-)
1. The area of a modern theater that is located between the curtain and the orchestra.
2. The stage of an ancient theater, located between the background and the orchestra.

“If you think about it, magic itself has many of the hallmarks of criminal activity: You lie, you cheat, you try not to get caught—but it’s on a stage, it has a proscenium around it. When Apollo walks onstage, there’s a sense that he might have one foot outside the proscenium. He takes a low crime and turns it into an art form.”

…..

Apollo is probably best known for an encounter with Jimmy Carter’s Secret Service detail in 2001. While Carter was at dinner, Robbins struck up a conversation with several of his Secret Service men. Within a few minutes, he had emptied the agents’ pockets of pretty much everything but their guns. Robbins brandished a copy of Carter’s itinerary, and when an agent snatched it back he said, “You don’t have the authorization to see that!” When the agent felt for his badge, Robbins produced it and handed it back. Then he turned to the head of the detail and handed him his watch, his badge, and the keys to the Carter motorcade.

via An excellent article titled “A Pickpockets Tale” in the New Yorker

 

 

Knee Jerk Reactions and Underlying Trends

I think this is an interesting question and I’m not even sure I know the answer.  So I decided to see what people on the facebook post think.

First, some updated info:
- In fact, there have always been school shootings but they became substantially more common in the 90s http://en.wikipedia.org/wiki/List_of_school_shootings_in_the_United_States
- Those are actually Daisy Model 25 hand pump BB guns.  Those girls might be German.  Their legs are definitely sexy.
- A lot of people had shooting ranges at their high schools up until the 80s but those were mostly for ROTC people.  Lots of schools had competitive rifle/shooting teams.

There were about 1400 comments on that facebook post and I skimmed a good deal of them.  If there’s anything I’ve learned from this exercise it’s that the reading/writing/comprehension skills of people on facebook indicate that schools definitely aren’t doing their jobs.  Based on my arbitrary reading, I’ve ranked the reasons that people think society has gotten more violent below:
- Violent video games and movies
- Widespread pharmaceutical prescriptions ?!?
- We have taken god and morals out of schools
- Rap music / gang culture
- Congress has legislated against personal responsibility
- Kids don’t respect anything anymore
- Progressive ideals twist children’s minds
- The government has made us weak!!
- Tripled population growth?!?
- Schools being gun free zones
- Republicans or Democrats respectively
- Parents and Teachers are not allowed to beat children anymore (libtards!)
- No longer threat of soviet invasion
- Sex education / gays / feminism
- Excessive homework / texting
- Women in the workplace / union busting / vaccines (personal favorite)
- Socialism has made “every man a slave end socialism and end school shootings”
- Insurance premiums!?! / political correctness
- Nancy Pelosi / Barack Obama
- Open sexual practices (those legs!)

I might do a bit more research on this but I don’t think any of these adequately answer the question.

 

Could You Speak Up A Little?

“Transit authorities in cities across the country are quietly installing microphone-enabled surveillance systems on public buses that would give them the ability to record and store private conversations, according to documents obtained by a news outlet.  The systems are being installed in San Francisco, Baltimore, and other cities with funding from the Department of Homeland Security in some cases, according to the Daily, which obtained copies of contracts, procurement requests, specs and other documents.”  -Public Buses Across Country Quietly Adding Microphones via Wired Threat Level.  Constant surveillance makes our country into a police state.  Ewwww

The Drone Father

“When I started, people asked why I was making a UAV with four times the computational power of the F-16, the first fly-by-wire jet fighter,” says Mr Karem. The reason was that, as any computer buyer knows, a more powerful machine takes longer to become obsolete. “Almost all of our subsystems from 1985-89 are still flying in some Predators today,” says Mr Karem, “including its 27-year-old computer and, with minor changes, the ground station.”

:: The Drone Father via The Economist via @cloudchloe ::

Let’s Talk about Dance

Hellzapoppin from Whitey’s Lindy Hop Crew, the best Lindy Hop I’ve ever seen

Swing Republic feat Bing Crosby – On The Downbeat

Charleston Style, Sync’d to Daft Punk’s Around the World

 

I think it’s interesting to contrast this against what Marques Scott is doing with Dragon House

Happy Sagan Day! November 9, 1934

“In some respects, science has far surpassed religion in delivering awe. How is it that hardly any major religion has looked at science and concluded, “This is better than we thought! The Universe is much bigger than our prophets said, grander, more subtle, more elegant. God must be even greater than we dreamed”? Instead they say, “No, no, no! My god is a little god, and I want him to stay that way.”

Car Sagan, Pale Blue Dot: A Vision of the Human Future in Space